免疫检查点抑制剂治疗在甲状腺癌中的有效性:系统性审查
Jennifer Tasong1, Rocco Sheldon1, Avi Clements1
1University of Birmingham College of Medicine and Health, Birmingham, United Kingdom.
Cancer treatment reviews
|November 5, 2025
概括
免疫检查点抑制剂 (ICI) 在甲状腺癌中表现有前途,特别是像甲状腺癌 (ATC) 这样具有攻击性的亚型. 需要进一步的研究来证实它们在更大的试验中的有效性和安全性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
背景情况:
- 甲状腺癌的发病率正在上升,具有高死亡率的侵袭性亚型.
- 免疫检查点抑制剂 (ICI) 在各种固体瘤中显示出有效性.
- 在甲状腺癌中ICI的作用需要进一步研究.
研究的目的:
- 系统地审查ICI在甲状腺癌中的有效性和安全性.
- 根据PRISMA指南评估ICI的有效性和安全性.
- 使用ICI确定甲状腺癌的最佳治疗策略.
主要方法:
- 在6个主要数据库 (EMBASE,PubMed,CENTRAL,Scopus,Web of Science,Clinicaltrials.gov) 进行系统的文献搜索,截至2025年1月10日.
- 包括所有报告ICI在甲状腺癌中的疗效结果的研究.
- 使用CASP检查清单进行质量评估,并审查正在进行的试验.
主要成果:
- 33项研究符合纳入标准,评估了各种ICI组合 (与TKI,化疗,放射治疗或双重ICI).
- 生物标志物分层ICI组合在形甲状腺癌 (ATC) 中表现出最大的有效性.
- 常见的不良事件包括疲劳,厌食症和脂酶增加;安全性概况一般是可控的.
结论:
- ICI在甲状腺癌,特别是ATC中显示出有希望的反应.
- 目前的证据仅限于I-II期研究;需要进行III期试验.
- 预测生物标志物对于识别可能受益的患者和最大化成本效益至关重要.
关键词:
无塑性甲状腺癌是一种无塑性甲状腺癌.生物标志物 生物标志物有效性 有效性.免疫检查点抑制剂 免疫检查点抑制剂免疫治疗是一种免疫疗法.安全的安全的安全的安全的安全.系统性审查 系统性审查甲状腺癌是什么?甲状腺癌是什么?更多相关视频
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