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表面工程RNA纳米粒子用于有针对性和高效的肝细胞癌药物输送

Nayoung Youn¹, Sunghyun Moon¹, Iksoo Jang¹

¹Department of Chemical Engineering, University of Seoul, Seoul 02504, Republic of Korea.

Biomedical materials (Bristol, England)

|November 5, 2025

概括

装载着多克索鲁比的新RNA纳米颗粒专门准肝癌细胞. 这种向药物递送系统提高了化疗的疗效,并通过利用Tri-GalNAc对肝细胞癌治疗的配体来减少副作用.

科学领域:

生物技术是生物技术.
纳米医学是一种纳米医学.
在瘤学瘤学.

背景情况:

化疗面临着药物溶解性,药理动力学和非标毒性方面的挑战.
系统性药物输送可能会损害健康细胞,限制治疗结果.
有针对性的输送系统对于提高癌症治疗的有效性和安全性至关重要.

研究的目的:

开发Tri-GalNAc装饰的RNA纳米颗粒 (RNAP) 用于向向肝细胞癌 (HCC) 输送多克索鲁比 (Dox).
为了提高多克索鲁比的治疗效果,同时最大限度地减少全身副作用.
调查结合体修饰RNAPs在向癌症治疗中的潜力.

主要方法:

构建了装饰着Tri-GalNAc的RNA纳米粒子 (Dox-TG-RNAP),装载着多克索鲁比.
功能化的RNAP表面与avidin和biotin-Tri-GalNAc使用静电和非共价相互作用.
评估了Dox-TG-RNAP在表达亚亚糖蛋白受体 (ASGPR) 的HCC细胞和健康细胞中的向特异性和细胞毒性.

主要成果:

Dox-TG-RNAP显示出高的多克索鲁比辛负载能力.
证实了通过ASGPR介导的内细胞分裂向HCC细胞的向输送多克索鲁比辛.
在表达ASGPR的HCC细胞中选择性诱导亡,对非表达ASGPR的细胞 (例如HDF细胞) 具有最小的毒性.

结论:

装饰着Tri-GalNAc的RNAP提供了一个有前途的平台,用于在HCC治疗中向输送多克索鲁比辛.
RNAP的联体修饰有效地向癌细胞,减少非向效应和全身毒性.
这种方法有可能通过表面功能化开发用于各种癌症的先进纳米药物.

关键词:

在ASGPR的基础上,ASGPR是ASGPR.在RNA纳米技术上.三-加NAccc 的使用情况.化学疗法化疗化疗有针对性的药物输送.

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