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在NMOSD和MOGAD中血C1q,C3和C4的临床值

Yuqing Wu¹, Hao Zhuo², Xianpeng Zhang¹

¹The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine),310000, Hangzhou, China.

Multiple sclerosis and related disorders

|November 5, 2025

概括

降低的血补充水平 (C1q,C3,C4) 将神经omyelitis optica光谱障碍 (NMOSD) 与MOGAD区分开来. 这些水平与残疾和BBB中断相关,在NMOSD中具有独特的反相关性,表明不同的病理生理学.

科学领域:

神经免疫学神经免疫学
补充系统生物学补充系统生物学
自免疫神经学自免疫神经学

背景情况:

神经脊髓炎光学谱系障碍 (NMOSD) 和MOG抗体相关疾病 (MOGAD) 是罕见的中枢神经系统自身免疫性疾病.
补体系统在NMOSD和MOGAD发病过程中的作用是不同的.
了解这些差异对于准确的诊断和治疗至关重要.

研究的目的:

为了研究NMOSD和MOGAD患者之间主要血补充水平的差异.
在这些条件下分析血补充水平与疾病特征之间的相关性.

主要方法:

对33名MOGAD患者,62名NMOSD患者和49名健康对照者的回顾性分析.
血和CSF免疫球蛋白G (IgG) 和专蛋白的量化.
对血补充因子 (C1q,C3,C4) 的测量.
补充水平和临床参数之间的相关性分析.

主要成果:

与MOGAD相比,NMOSD患者的女性占主导地位和复发率更高.
血C1q,C3和C4水平在NMOSD与MOGAD和对照中显著降低.
补充因子 (C1q,C3,C4) 在将NMOSD与MOGAD区分时显示出有用性.
血C3和C4与CSF白蛋白相关,而C1q与两组EDSS分数相关.
血C3和IgG指数之间的负相关性是NMOSD特有的.

结论:

降低的血补充水平 (C1q,C3,C4) 是NMOSD和MOGAD之间的关键区别.
在这两种疾病中,补充水平反映了疾病残疾和血脑屏障的破坏.
在NMOSD中,C3和IgG指数之间的特定反相关性表明了一个独特的病理生理机制.

关键词:

在C1qq.C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C3 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 C4 的IgG指数.髓寡细胞糖蛋白抗体疾病抗体视觉神经炎光学谱系障碍这就是Q-Alb.

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