Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.3K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.3K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.4K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The Incidence of Subsequent Cervical Spine Surgery after Cervical Disc Arthroplasty, a Minimum Two-year Follow-up.

Journal of surgical orthopaedic advances·2022
Same author

Scx<sup>Lin</sup> cells directly form a subset of chondrocytes in temporomandibular joint that are sharply increased in Dmp1-null mice.

Bone·2020
Same author

Automated Measurement of Lumbar Lordosis on Radiographs Using Machine Learning and Computer Vision.

Global spine journal·2020
Same author

Detecting insertion, substitution, and deletion errors in radiology reports using neural sequence-to-sequence models.

Annals of translational medicine·2019
Same author

Predicting Surgical Complications in Adult Patients Undergoing Anterior Cervical Discectomy and Fusion Using Machine Learning.

Neurospine·2018
Same author

Predicting Surgical Complications in Patients Undergoing Elective Adult Spinal Deformity Procedures Using Machine Learning.

Spine deformity·2018

相关实验视频

Updated: Jan 12, 2026

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
09:30

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

19.0K

用多能干细胞模型探索精神分裂症中的海马功能障碍.

Deepak Kaji1

  • 1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, NYC, NY, 10029, United States of America.

Schizophrenia research
|November 5, 2025
PubMed
概括

人类多能干细胞衍生的海马体有机体为研究精神分裂症提供了一个新的体外模型. 这些模型对理解神经发育的起源和查治疗这种复杂的大脑疾病的治疗方法充满希望.

科学领域:

  • 神经科学是一个神经科学.
  • 干细胞生物学 干细胞生物学
  • 精神病学研究 精神病学研究

背景情况:

  • 精神分裂症是一种影响认知和行为的神经发育障碍,其中涉及海马体功能障碍.
  • 传统的研究模型 (动物,死后) 在捕捉精神分裂症的人类特异性和发育方面的局限性.
  • 人类多能干细胞 (hPSC) 衍生的脑器官正在成为研究精神疾病的强大工具.

研究的目的:

  • 审查精神分裂症中海马功能障碍的发育基础.
  • 讨论hPSC衍生的海马体有机体和组合体在模拟精神分裂症方面的潜力.
  • 确定挑战,并提出海马体有机体技术在精神分裂症研究中的未来方向.

主要方法:

  • 关于海马发育和精神分裂症的现有文献的综述.
  • 分析使用hPSC衍生的海马体器官和组合物的研究.
  • 探索潜在电路建模 (DG-CA3,皮质-海马体,海马体-状体).

主要成果:

  • 海马体有机体模型尚不发达,但显示出研究精神分裂症的潜力.
  • 有限的研究突出了模型特定海马子电路的能力.
  • 关键的挑战包括缺乏CA1/CA2子场,有限的血管化和微质缺乏.
关键词:
皮层 皮层 皮层遗传学 是一个遗传学.神经发育 神经发育器官类动物 器官类动物干细胞生物学 干细胞生物学在海马体内,海马体

更多相关视频

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.3K
Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.9K

相关实验视频

Last Updated: Jan 12, 2026

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
09:30

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

19.0K
2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
14:19

2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

Published on: March 25, 2022

4.3K
Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders
05:00

Transplantation of Human Stem Cell-Derived GABAergic Neurons into the Early Postnatal Mouse Hippocampus to Mitigate Neurodevelopmental Disorders

Published on: November 11, 2022

2.9K

结论:

  • 由hPSC衍生的海马体有机体是精神分裂症研究的一个有希望的,但尚未充分利用的平台.
  • 完善这些模型对于机械学发现和治疗查至关重要.
  • 整合遗传,成像和发育数据将促进对精神分裂症神经发育起源的理解.