患有Enterococcus faecalis血流感染的患者中结直肠癌的患病率:一项全国性的研究
L Østergaard1, A Dahl1, S Chamat-Hedemand2
1Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
The Journal of infection
|November 5, 2025
概括
患有Enterococcus faecalis血流感染 (BSI) 的患者患结直肠癌 (CRC) 和结直肠瘤 (CRN) 的风险更高. 然而,绝对风险增加并不支持这些患者的常规CRC查.
科学领域:
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 以前的研究表明,Enterococcus faecalis血流感染 (BSI) 和结直肠癌 (CRC) 之间存在联系.
- 这些先前的研究受到小样本大小和低概括性的限制.
- 需要进一步的研究来澄清这种关联及其临床影响.
研究的目的:
- 调查首次Enterococcus faecalis BSI和随后结直肠癌 (CRC) 和结直肠瘤 (CRN) 的风险之间的关联.
- 确定观察到的关联是否需要在患有E. faecalis BSI.的患者中进行系统的CRC查.
主要方法:
- 利用丹麦全国性的登记册来识别首次感染E. faecalis BSI的患者 (2010-2021年).
- 根据年龄,性别和日历,与一般人群中的比较者相匹配的患者比例为 1:5.
- 估计了CRC和CRN的六个月累积发病率,并进行了多变量Cox分析.
主要成果:
- 确定了4664名患有E. faecalis BSI的患者和23320名匹配的对照者.
- 在BSI患者中,CRC的六个月发病率为0.45%,比较者为0.12%;CRN的发病率为2.34%比0.48%.
- 调整后的分析显示,在E. faecalis BSI患者中,CRC (3.70) 和CRN (4.64) 的HR显著更高. 在BSI患者中,六个月死亡率为36.3%,比较者为1.7%.
结论:
- 与一般人群相比,首次感染E. faecalis BSI的患者的CRC和CRN发病率是CRC和CRN的3-4倍.
- 尽管相对风险增加,但该队列中CRC和CRN的绝对风险并不能证明常规查是合理的.
- 与E. faecalis BSI相关的高死亡率凸显了它的严重程度.
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