失眠的全球和区域形态相似性与客观的短睡眠时间相似
Zhangwei Lv1, Haobo Zhang1, Yuhan Fan1
1Sleep and NeuroImaging Center, Faculty of Psychology, Southwest University, Chongqing 400715, China; Key Laboratory of Cognition and Personality (Southwest University), Ministry of Education, Chongqing 400715, China.
Progress in neuro-psychopharmacology & biological psychiatry
|November 5, 2025
概括
失眠障碍呈现出不同的亚型,具有不同的睡眠模式和大脑结构. 识别这些表型,如短睡眠时间失眠,是开发向治疗的关键.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 失眠障碍是异质的,有不同的心理和神经生物学基础.
- 精确的表型定型对于开发有效,有针对性的失眠干预措施至关重要.
- 客观总睡眠时间 (oTST) 可以区分失眠表型.
研究的目的:
- 调查失眠表型之间的睡眠参数,心理特征和形态相似性 (MS) 的差异.
- 为了比较失眠与客观正常睡眠持续时间 (INSD) 和失眠与客观短睡眠持续时间 (ISSD) 现型.
- 探索与不同的失眠亚型相关的神经生物学机制.
主要方法:
- 一项临床对照研究涉及997名成年失眠患者,其中270人接受了MRI.
- 基于通过可穿戴的额头睡眠记录仪测量的oTST进行表型鉴定.
- 通过MS映射评估睡眠参数,心理特征 (如反) 和MS模式.
主要成果:
- ISSD表型在睡眠开始后表现出更短的清醒时间,更低的REM百分比,以及更高的非REM阶段2百分比.
- INSD表型显示出更大的睡眠感知偏差和更分散的睡眠.
- ISSD显示了全球和区域MS的变化,包括网络脱和脱差.
结论:
- 不同的神经生物学机制是不同失眠表型的基础.
- 基于表型的干预措施是有效治疗失眠的必要条件.
- 形态相似度映射揭示了失眠亚型中的结构性大脑差异.
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