在日本成年人中,肠道活性细菌与阻塞性睡眠呼吸暂停严重程度之间的关联
Masako Ueyama1, Ryuji Ohue-Kitano2, Ikuo Kimura3
1Sleep Apnea Syndrome Treatment Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, 3-1-24 Matsuyama, Kiyose, Tokyo, Japan; Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo, Japan.
Respiratory medicine
|November 5, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与肠道细菌的变化有关,特别是日本成年人Bifdobacterium的增加. 这表明Bifdobacterium可能有助于在OSA的低氧压力期间保持肠道健康.
科学领域:
- 微生物组研究的研究.
- 睡眠的药物 睡眠的药物
- 人类生理学 人类生理学
背景情况:
- 肠道微生物群影响健康,并受到缺氧的影响.
- 之前关于间歇性缺氧和肠道微生物群的研究使用动物模型.
- 阻塞性睡眠呼吸暂停 (OSA) 对日本成年人肠道微生物群的影响尚不清楚.
研究的目的:
- 调查日本成年人OSA严重程度和肠道微生物群组成之间的关联.
- 探索OSA中常见的缺氧如何影响肠道微生物群.
主要方法:
- 对74名被诊断患有OSA的日本成年人进行横截面研究.
- 分析便样本以确定肠道微生物群的组成.
- 3%氧气脱度指数 (ODI) 与菌群,家族和属水平上的微生物群之间的相关性分析.
主要成果:
- 在3%的ODI和Actinobacteria (包括Bifidobacteriaceae) 之间发现了显著的正相关性,在类级别上与Firmicutes之间发现了负相关性.
- 与其他细菌群体相比,Bifidobacterium在OSA患者中显著增加.
- 没有观察到与蛋白质细菌或细菌菌有显著的相关性.
结论:
- 日本成年人患有OSA的肠道微生物组显示Bifdobacterium的增加.
- 与OSA相关的间歇性缺氧可能会导致肠道微生物群的这些观察到的变化.
- 在这种人群中,高Bifdobacterium可能在低氧压力下维持肠道平衡中发挥作用.
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