生活方式干预比糖尿病前期更有效地恢复β细胞功能,减少子宫外脂肪,并预防2型糖尿病
Yiying Wang1, Arvid Sandforth1, Reiner Jumprtz-von Schwartzenberg2
1Institute for Diabetes Research and Metabolic Diseases of Helmholtz Munich at the University of Tübingen, Otfried-Müller-Str. 10, 72076 Tübingen, Germany; German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, 85764, Neuherberg, Germany; Department of Internal Medicine IV, Diabetology, Endocrinology and Nephrology, Eberhard-Karls University Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Germany.
1小时后高血葡萄糖 (1h-PG) 表示一种中间代谢状态. 生活方式干预显著改善了高1h-PG的个体的葡萄糖调节,并降低了2型糖尿病的风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 糖尿病研究 糖尿病研究
背景情况:
- 1小时后高血葡萄糖 (1h-PG) 是糖尿病风险的早期指标.
- 这项研究调查了孤立的高1h-PG是否代表正常葡萄糖调节 (NGR) 和受损葡萄糖调节 (IGR) 之间的中间代谢状态.
研究的目的:
- 评估与孤立高1h-PG.个体的代谢特征.
- 评估生活方式干预 (LI) 对该群体葡萄糖调节和糖尿病风险的影响.
- 将高1h-PG组的结果与NGR和IGR组的结果进行比较.
主要方法:
- 图宾根生活方式干预计划涉及317名NGR,IGR或孤立高1h-PG的参与者.
- 参与者接受了为期9个月的LI计划,其目标是减肥≥5%.
- 在LI之前和之后评估了代谢参数,包括胰岛素敏感性,β细胞功能,内脏脂肪组织 (VAT) 体积和肝脂肪含量.
主要成果:
- 胰岛素敏感性和β细胞功能逐渐下降,从NGR到高1h-PG到IGR.
- 在高1h-PG群体中,LI改善了胰岛素敏感性和β细胞功能,达到NGR水平,肝脂肪减少.
- 与IGR组相比,高1h-PG组显示2型糖尿病 (T2D) 的风险降低了80%,并且在12年内,正常血糖减缓的几率翻了一番.
结论:
- 高的1h-PG表示一种中间代谢状态,其变化比NGR更严重,但比IGR小.
- 与IGR相比,高1h-PG个体的LI改善了代谢功能,减少了宫外脂肪,并降低了T2D风险.
- 1h-PG是早期干预的宝贵生物标志物,可逆转导致糖尿病前期和T2D的代谢缺陷.
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