前卵泡计数和抗穆勒尔激素对卵巢反应和妊娠率在试管婴儿前性循环中的预测价值
Selina Tsz Ching Lee1, Rebecca Siu Fan Wan1, Shui Fan Lai2
1Department of Obstetrics and Gynecology, Princess Margaret Hospital, Kowloon, Hong Kong.
概括
前卵泡计数 (AFC) 和抗穆勒尔激素 (AMH) 在试管婴儿的孕激素协议中预测卵细胞产量. AMH也可以预测卵巢的反应,但这两种标记都不能预测怀孕的结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 卵巢反应预测对于优化试管婴儿结果至关重要.
- 前毛囊数 (AFC) 和抗穆勒尔激素 (AMH) 是已确立的卵巢储备的标志物.
- 孕激素预制方案是IVF中常见的卵巢刺激策略.
研究的目的:
- 通过使用孕激素协议评估AFC和AMH在IVF期间卵巢反应的预测价值.
- 评估AFC和AMH与该患者队列中的怀孕率的关联.
主要方法:
- 追溯分析779名患者进行了他们的第一个试管婴儿循环与孕激素-priming协议.
- 在刺激前进行过阴道超声波以测量AFC和血液检测AMH水平.
- 分析了卵巢反应 (取卵细胞,高/低反应) 和怀孕率.
主要成果:
- 无论是AFC还是AMH,都与检索的卵细胞数量有显著的相关性 (P < 0.001).
- AMH,但不是AFC,显著预测了高和低水平的卵巢反应 (P < 0.001).
- 无论是AFC还是AMH都不是怀孕率的重要预测因素.
结论:
- AFC和AMH是孕激素为基础的试管婴儿周期中卵细胞产量的有价值的预测因素.
- 与AFC相比,AMH显示了卵巢反应的优异预测性能.
- 目前的标记 (AFC,AMH) 在本协议中无法可靠地预测怀孕的成功.
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