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高脂肪饮食通过肠道微生物组的改变加剧了亚托皮炎
Keito Tabata1, Nobutomo Ikarashi1, Ryotaro Yoshida1
1Department of Biomolecular Pharmacology, Hoshi University, Tokyo, Japan.
The Journal of nutritional biochemistry
|November 5, 2025
概括
高脂肪饮食会通过改变肠道细菌和减少有益的短链脂肪酸 (SCFA) 来恶化亚托皮炎 (AD). 乙酸补充剂可以缓解AD症状,表明其治疗潜力.
科学领域:
- 皮肤病学 皮肤病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 亚托皮炎 (AD) 是一种慢性皮肤疾病,受遗传和饮食等环境因素的影响.
- 高脂肪饮食 (HFDs) 被怀疑是AD恶化的贡献者,但潜在的机制需要进一步调查.
研究的目的:
- 为了研究高脂肪饮食对亚托邦性皮肤炎病变的影响.
- 探索肠道微生物群和短链脂肪酸 (SCFA) 在HFD引起的AD恶化中的作用.
主要方法:
- 在食正常或高脂肪饮食 (HFD) 的小鼠中诱导了亚托皮炎.
- 量化了皮肤炎症标志物和AD相关因素.
- 分析了肠道微生物群组成和内含量的SCFA水平.
- 进行了便微生物群移植和酸乙酸剂的使用.
主要成果:
- HFD显著增加了皮肤上的炎症标志物和AD相关因素.
- HFD改变了肠道微生物群,减少了产生SCFA的细菌 (Bacteroides acidifaciens,Parabacteroides distasonis) 并降低了SCFA水平.
- 便微生物种移植证实了肠道失调和AD恶化之间的联系.
- 乙酸盐的使用改善了HFD诱导的皮肤炎症和AD类症状.
结论:
- 摄入高脂肪饮食会通过肠道微生物群的变化和减少SCFA的产生,加剧类似于亚托皮炎的症状.
- 乙酸和产生乙酸的细菌显示出潜在的治疗策略来管理AD.
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