人工智能驱动的衰老数字双胞胎:精密老年病学临床翻译的路线图
Chenchen Li1, Ke Zuo2, Ruijia Duan1
1Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China; Clinical Medical Research Center for Stroke Prevention and Treatment of Hunan Province, Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
由人工智能 (AI) 驱动的老化数字双胞胎 (ADT) 通过整合各种数据进行实时健康监测和早期疾病检测,为老化提供个性化药物. 然而,数据偏差和道德问题等挑战需要进一步的研究,以便广泛的临床使用.
科学领域:
- 老年学和计算生物学.
- 专注于衰老,疾病和人工智能的交叉点.
背景情况:
- 老龄化增加了对神经退行性疾病,心血管疾病和癌症等主要疾病的易感性,占全球死亡率的70%.
- 目前的治疗方法受到不准确的诊断和缺乏个性化治疗选择的限制.
- 对于老龄化人口的精准医学中先进解决方案的需求至关重要.
研究的目的:
- 审查人工智能支持的衰老数字双胞胎 (ADT) 在对衰老的精准医学进行革命的潜力.
- 检查与ADT实施相关的技术和道德挑战.
- 突出ADT在健康监测,预测分析和个性化干预方面的能力.
主要方法:
- 使用先进的人工智能和深度学习算法集成多源异质数据.
- 为实时健康监测和预测分析开发虚拟双胞胎.
- 关于人工智能在老化和数字双胞胎技术中的应用现有文献的审查.
主要成果:
- 由人工智能驱动的ADT显示了实时健康监测,预测分析和个性化干预的巨大潜力.
- 虚拟双人可以促进早期疾病检测,风险评估和优化治疗策略.
- 确定的挑战包括训练数据中的年龄分层偏见,数据质量变化,隐私问题,算法透明度和临床验证.
结论:
- 人工智能支持的ADT代表了针对衰老的精准医学的变革性方法.
- 解决技术限制,如数据偏差和质量,对于模型通用性至关重要.
- 必须解决伦理方面的考虑,包括数据隐私和算法透明度,以获得成功的临床采用.
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