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患有唐氏综合征的儿科患者甲状腺激素配置的与年龄相关的变化
Machiko Toki1,2, Satoshi Narumi1, Junko Hanakawa2
1Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan.
Endocrine journal
|November 5, 2025
概括
唐氏综合征 (DS) 儿童的甲状腺刺激激素 (TSH) 水平通常高于对照组. 甲状腺激素样本显示与年龄相关的变化,需要个性化的甲状腺功能管理在DS患者.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 遗传学和遗传性疾病
- 内分泌学 在内分泌学.
背景情况:
- 患有唐氏综合征 (DS) 的儿童表现出高发生率的甲状腺功能障碍.
- 在DS中甲状腺激素配置的与年龄相关的变化尚未得到充分理解.
- 甲状腺功能监测对于DS患者的健康管理至关重要.
研究的目的:
- 为了研究患有唐氏综合征的儿童甲状腺功能与年龄相关的变化.
- 为了比较DS患者和年龄相匹配的对照人群之间的甲状腺激素概况.
- 评估先天性心脏病 (CHD) 和胃肠道形对DS中的甲状腺功能的影响.
主要方法:
- 在762名没有已知的甲状腺疾病的DS患者 (3-14岁) 中,对甲状腺功能测试 (TSH,FT3,FT4) 的回顾性分析.
- 与764个年龄相匹配的对照组进行了比较,这些对照组具有特异性矮身.
- 在DS患者中分析甲状腺激素水平,包括有或没有心脏病和胃肠道形.
主要成果:
- 与所有年龄组的对照人群相比,患有DS的患者始终显示出更高的TSH平均水平.
- 在某些年龄段之后,DS组的平均FT3和FT4水平略低,在较年轻的DS儿童中,FT3/FT4比率较低.
- 患有心血管疾病的DS患者在11岁后的TSH水平高于没有心血管疾病的患者.
结论:
- 在TSH分布的一般向右转移表明TSH在DS患者中升高,即使没有诊断出甲状腺疾病.
- 在DS儿童中,甲状腺激素的特征表现出特定年龄的变化.
- 个性化的甲状腺功能管理策略对于患有唐氏综合征的儿童至关重要.
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