多次选择性手术和带血移植,用于多重耐火单态表皮性肠道T细胞淋巴瘤
Miki Watanabe1, Yu Nakashima2, Yurika Yamada3
1Department of Hematology and Oncology, Toyohashi Municipal Hospital, Japan.
Internal medicine (Tokyo, Japan)
|November 5, 2025
概括
单形上皮类型的肠道T细胞淋巴瘤 (MEITL) 是罕见的. 本案例研究强调了通过手术和异构移植成功治疗耐火性MEITL.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 血液学 血液学 血液学
背景情况:
- 单形上皮类型肠道T细胞淋巴瘤 (MEITL) 是一种极为罕见和激进的非霍奇金淋巴瘤形式.
- MEITL通常表现为胃肠道症状,预后不佳,往往治疗选择有限.
研究的目的:
- 报告一例耐火性MEITL病例,该病例通过外科干预和全原干细胞移植的组合成功治疗.
- 探索将选择性手术与异构移植整合为复发性或耐火性MEITL的可行治疗策略的潜力.
主要方法:
- 经小肠内镜检查证实了MEITL的诊断.
- 该患者经历了多种治疗方式,包括化疗,救援方案,部分阴茎切除,卵巢切除,最终,带血移植.
主要成果:
- 尽管在一线化疗后的初步进展和对多种救援方案的折射性,但患者实现了完全缓解.
- 患者在结合治疗方法后在诊断后的37个月内仍然活着并处于缓解状态.
结论:
- 手术干预,包括切除和卵巢切除,在控制疾病进展方面发挥了至关重要的作用.
- 在手术管理后,全基性带血移植为复发性或耐药性MEITL患者提供了潜在的治疗选择.
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