对内脏脂肪组织与肥胖相关疾病的关联的横截面分析
Adam W Potter1, Karl E Friedl1
1U.S. Army Research Institute of Environmental Medicine, Natick, MA, United States.
The American journal of clinical nutrition
|November 5, 2025
概括
内脏脂肪组织 (VAT) 在预测代谢综合征和2型糖尿病等与肥胖相关的疾病方面表现有前途. 大约100平方厘米的增值税门可能表明代谢疾病的风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性疾病研究研究
- 肥胖研究 肥胖研究
背景情况:
- 像BMI和WC这样的传统肥胖指标在预测代谢疾病方面存在局限性.
- 内脏脂肪组织 (VAT) 是代谢疾病风险的更直接的指标.
- 增值税估计的进步使实际风险评估成为可能.
研究的目的:
- 为了测试假设,增值税是代谢综合征,2型糖尿病 (T2DM) 和胰岛素抵抗的更强的预测因素,而不是BMI,%BF或WC.
- 为此分析,利用国家健康和营养检查调查 (NHANES) 的数据.
主要方法:
- 对来自4139名男性和4147名女性 (年龄在18-59岁之间) 的横截面NHANES数据 (2011-2018) 的分析.
- 测量包括BMI,%BF,WC,WC/高度和VAT (双能X射线吸收计).
- 代谢综合征 (MetS),T2DM和胰岛素抵抗 (HOMA-IR) 被评估为结果.
主要成果:
- 增值税在MetS (AUC 0.84),T2DM (AUC 0.80) 和HOMA-IR (AUC 0.79) 的分类表现很高.
- 已识别的增值税风险门:MetS (103厘米2),T2DM (119厘米) 和HOMA-IR (84厘米).
- 腰围 (WC) 在一些比较中显示出与增值税相似的表现.
结论:
- 增值税估计可能会增强个人肥胖风险管理.
- 这项研究并没有表明,增值税对简单的WC或WC/高度测量有明确的优势.
- 建议在增值税≥100平方厘米时为代谢性疾病风险设定潜在的性别独立值.
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