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Updated: May 12, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

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在氧尿素不耐受性或氧尿素耐火性基本血栓细胞血症 (SURPASS ET) 中使用Ropeginterferon alfa-2b:多中心,开放标签,随机,主动控制的第三阶段研究

Ruben Mesa1, Harinder Gill2, Lei Zhang3

  • 1Atrium Health, Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, USA.

The Lancet. Haematology
|November 5, 2025
PubMed
概括

与阿纳格雷利德相比,罗佩干扰素α-2b显示出更高的疗效,作为二线治疗白血球性基本血栓塞病的二线治疗. 这种新疗法对不耐受或耐受氧尿素的患者提供了显著的改善.

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...