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Updated: Jan 12, 2026

Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity
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Drug-Induced Senescence in Liver Cells Promotes M2 Macrophage Polarization: Implications for Tyrosine Kinase Inhibitor-Associated Hepatotoxicity

Published on: October 17, 2025

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通过USP2-介导的PPARγ稳定促进肝细胞癌的进展,并通过油酸促进M2巨的两极分化

Jing Cao1,2,3, Kui Chen4, Kuan Hu4

  • 1Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Journal for immunotherapy of cancer
|November 5, 2025
PubMed
概括

准泛素特异蛋白酶2 (USP2) 通过破坏脂质代谢和诱导铁亡,抑制肝细胞癌 (HCC) 的生长. 抑制USP2也调节了巨细胞的透,为HCC提供了潜在的治疗策略.

关键词:
免疫治疗是一种免疫疗法.巨细胞是一个巨细胞.

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