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Updated: Jan 12, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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突变的p53结合并控制雌激素受体活性,以驱动卵巢癌中的内分泌抵抗

Chunlei Shao1, Alexandra Indeglia1, Maya Foster1,2

  • 1Program in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

Genes & development
|November 5, 2025
PubMed
概括

突变p53阻碍卵巢癌中的雌激素受体α (ERα),导致内分泌疗法耐药性. 沉默突变p53恢复ERα功能,改善高度血清性卵巢癌 (HGSOC) 的治疗灵敏度.

关键词:
内分泌疗法是一种内分泌疗法.雌激素受体的受体是雌激素受体.突变的 p53 变种卵巢癌是发生在卵巢的癌症.

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