斯特里亚终端的床核-深层中脑核电路连接情绪和清醒
Zhongwen Zhang1,2,3, Yoan Cherasse4,2, Chandra Louis2
1Institute of Medicine, University of Tsukuba, Tsukuba 305-8575, Japan.
概括
终端 (BNST) 电路的床核通过激活深层中大脑核 (DpMe) 神经元来促进兴奋. 这条涉及情绪刺激的途径可能是治疗睡眠障碍的目标.
科学领域:
- 神经科学是一个神经科学.
- 睡眠研究 睡眠研究
- 情绪调节 情绪调节 情绪调节
背景情况:
- 终端 (BNST) 的床核集成了情绪和兴奋信号.
- GABAergic BNST (GABABNST) 神经元参与睡眠-清醒过渡,但下游机制尚不清楚.
研究的目的:
- 确定通过GABABNST神经元促进兴奋的神经电路.
- 研究深层中脑核 (DpMe) 在这种兴奋途径中的作用.
主要方法:
- 光遗传学,光纤测量,神经切除和雄性小鼠的追踪.
- 使用c-fos mRNA表达和成像来评估神经元活动.
- 研究了带有狂犬病追踪和现场杂交的电路连接.
主要成果:
- 在DPMe中的GABABNST刺激诱导了快速的清醒,并激活了谷氨基基DpMe (GLUTDpMe) 神经元.
- 厌恶刺激激活了GLUTDpMe神经元,表明了情绪的突出.
- GLUTDpMe神经元剥离减弱了对GABABNST刺激的兴奋反应.
结论:
- 一个新的BNST-DpMe电路促进兴奋,允许情绪刺激取代睡眠.
- 这一途径可能会导致与压力相关的睡眠障碍.
- 该电路代表了与情绪失调相关的睡眠障碍的潜在治疗目标.
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