过去的轮班工作,黑激素受体基因多态化,以及退休工人中的高血血症:东-通吉队列研究
Tingting Mo1, Weidong Zhang1, Yufei Wang1
1Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sleep health
|November 5, 2025
概括
过去的轮班工作增加了超同囊血症的风险,尤其是在更长的时间内. MTNR1B rs10830963基因变异显著恶化了这种关联,突出了对轮班工作的遗传影响.
科学领域:
- 职业健康 职业健康 职业健康
- 遗传学 遗传学 是一个
- 心血管流行病学心血管流行病学
背景情况:
- 轮班工作在职业健康方面越来越令人担忧.
- 超高囊血是心血管疾病的危险因素.
- 遗传因素可能会影响个体对职业暴露的敏感性.
研究的目的:
- 为了检查过去轮班工作和高血糖蛋白血压之间的联系.
- 调查黑激素受体中的特定基因变异是否会改变这种关联.
主要方法:
- 分析了来自东-通吉队伍的14043名退休人员.
- 多变量逻辑回归用于评估轮班工作持续时间和高homocysteinemia.
- 对MTNR1A和MTNR1B变种的基因环境相互作用分析.
主要成果:
- 较长的过去轮班工作持续时间与更高的超同型囊血的几率显著相关 (或每5年增加:1.04 [1.02-1.06]).
- MTNR1B rs10830963加剧了轮班工作和高血糖蛋白血症之间的关联 (P-相互作用=.01).
- MTNR1A rs12506228显示了联合效应,但没有显著的相互作用 (P-相互作用=.89).
结论:
- 轮班工作对高homocysteinemia的有害影响在退休后仍然存在.
- 这种MTNR1B rs10830963基因变异改变了轮班工作和高homocysteinemia之间的关系.
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