关于外科手术期间的 gabapentinoids 的辩论:微妙的方法是最好的方法
Kishor Gandhi1, Eric S Schwenk2
1Anesthesiology, Virtua Memorial Hospital Burlington County, Mount Holly, New Jersey, USA.
Regional anesthesia and pain medicine
|November 5, 2025
概括
gabapentinoids 可以帮助减少阿片类药物的使用来治疗疼痛,但它们的使用需要仔细考虑,因为潜在的副作用,如镇静和呼吸抑制,特别是在老年患者.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 疼痛管理 疼痛管理
背景情况:
- 阿片类药物流行需要非阿片类药物疼痛管理策略.
- gabapentinoids (gabapentin,pregabalin) 正在研究术后疼痛,以减少对阿片类药物的依赖.
- 尽管已知的风险,但它们在治疗急性外科手术期间疼痛的非标签用途是常见的.
研究的目的:
- 在2025年讨论术前 gabapentinoids 的优点.
- 审查在手术患者中使用 gabapentinoid 的益处和风险.
- 倡导对 gabapentinoid 处方采取个性化的方法.
主要方法:
- 支持反对的讨论格式.
- 依赖已发表的证据.依赖已发表的证据.
- 专注于术后护理和疼痛管理.
主要成果:
- gabapentinoids 在减轻疼痛和节省阿片类药物方面提供了好处.
- 中枢神经系统的不良影响 (头,镇静) 是显著的,特别是在老年人.
- 与阿片类药物有协同呼吸系统抑郁的可能性和长期使用的认知缺陷.
结论:
- 在外科手术期间使用 gabapentinoid 需要对风险和益处进行均衡的评估.
- 个体患者的因素,特别是年龄和并发症,至关重要.
- 一种细微的,针对患者的具体方法对于最佳的疼痛管理和安全至关重要.
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