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Updated: Jan 12, 2026

Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells
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Zinc-finger Nuclease Enhanced Gene Targeting in Human Embryonic Stem Cells

Published on: August 23, 2014

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转录因子ZNF263将人类胚胎干细胞用于多能溶解和血统承诺

Qianqian Yin1, Jing Huang1,2, Hongduo Sun1,2

  • 1Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.

Nature communications
|November 5, 2025
PubMed
概括

转录因子ZNF263在人类胚胎干细胞 (hESC) 中建立了一个原始化的多能状态,促进对特定血统的分化. 它的缺失阻碍了这一至关重要的原始化过程.

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Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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