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Updated: Jan 12, 2026

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

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致癌的DEAD-box ATPase DDX41通过依赖和独立于CLK3的机制建立转录组合

Jeong-Ah Kim1, Siqi Shen2, Christina M Jurotich1

  • 1Wisconsin Blood Cancer Research Institute, Department of Cell and Regenerative Biology, Carbone Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Nature communications
|November 5, 2025
PubMed
概括

死亡盒ATPaseDDX41调节RNA剪接,影响骨髓原生转录组. 缺少DDX41会影响多个拼接步骤,并且需要Cdc2类激酶3 (CLK3) 进行某些功能.

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A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects TEdeff in Cancers10:49

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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