在更年期妇女中,循环内毒素与脂肪酸结合蛋白2和白细胞核因子-κB激活相关
Ting-Yu Chen1, Wan-Yu Huang2, Ko-Hung Liu1
1Translational Medicine Center, Chung Shan Medical University Hospital, Taichung, Taiwan.
Scientific reports
|November 5, 2025
概括
饭后的内毒素水平与绝经妇女的免疫细胞激活和全身炎症相关. 增加的肠道透性可能会导致这种由内毒素引起的炎症.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 循环内毒素,主要来自肠道细菌,在饭后增加.
- 内毒素在先天性免疫细胞反应和系统性炎症中的作用尚未完全理解.
研究的目的:
- 通过检查先天性免疫细胞反应来研究内毒素在全身炎症中的作用.
- 探索阴经期妇女内毒素水平,肠道屏障完整性和免疫激活之间的关系.
主要方法:
- 对禁食更年期妇女白细胞中内毒素水平,脂肪酸结合蛋白2 (FABP2),全身炎症标记物和核因子-卡帕B (NF-κB) 激活的分析.
- 在口服葡萄糖耐受性测试 (OGTT) 后对白细胞中NF-κB基因表达对食后内毒性影响的评估.
主要成果:
- 在禁食和OGTT后的白细胞中,在循环内毒素水平,FABP2和NF-κB激活之间发现了显著的关联.
- 即使是内毒素水平的微小变化 (约. 1欧元/毫升) 足以调节白细胞NF-κB激活.
- 研究结果表明,肠道屏障透性增加和内毒素引起的全身炎症之间存在联系.
结论:
- 餐后内毒症会影响先天性免疫细胞的激活,并导致全身炎症.
- 肠道屏障功能障碍可能是绝经期妇女内毒性相关炎症的关键因素.
- 对肠道微生物组和免疫相互作用的进一步研究是有必要的.
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