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中国缺血性中风患者的抗血小板治疗趋势 2019-2024年
Mingfen Wu1, Hailun Jiang1, Aning Sun1
1Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, People's Republic of China.
Scientific reports
|November 5, 2025
概括
在中国的缺血性中风患者中,抗血小板药物的使用从2019年至2024年增加. 阿司匹林仍然占主导地位和具有成本效益,尽管像提卡格勒罗尔这样的新药在增长,同时处方模式的经济和区域差异显著.
科学领域:
- 药物经济学 药物经济学
- 临床药房 临床药房
- 流行病学 流行病学
背景情况:
- 缺血性中风 (IS) 的管理严重依赖于抗血小板药物.
- 了解当前的处方趋势和经济因素对于优化中国患者护理至关重要.
- 以前的分析没有完全捕捉到抗血小板处方模式和成本的动态变化.
研究的目的:
- 分析中国缺血性中风患者中抗血小板药物使用的现状和趋势.
- 评估抗血小板处方的经济差异和区域差异.
- 确定影响药物选择和成本的关键因素.
主要方法:
- 一项横截面研究分析了来自中国医院处方分析数据库 (2019-2024) 的1,505,850份处方.
- 曼-肯达尔试验用于对处方和成本的趋势分析;对药物比例变化的日志线性模型.
- 确定每日成本 (DDC) 计算,以评估经济变化和区域差异.
主要成果:
- 总的抗血小板药物处方显著增加 (2019-2024年),阿司匹林占主导地位 (52.7%),但克洛皮多格雷尔使用量有所下降.
- 蒂卡格勒罗和印多布芬显示出快速增长,同时观察到显著的经济差异,阿司匹林是最具成本效益的药物.
- 在处方增长和确定每日成本 (DDC) 中发现了显著的区域差异,这表明获取和利用方式各不相同.
结论:
- 中国IS患者的抗血小板处方数量有所上升,其特点是阿司匹林的持续主导地位和新药的增长.
- 显著的经济和区域差异需要针对指导方针和政策进行针对性优化,以优化抗血小板药物策略.
- 不断变化的治疗环境需要持续监测,以确保对缺血性中风患者提供成本效益和公平的护理.
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