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Updated: Jan 12, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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突变的p53变体对复制启动产生差异影响,并激活cGAS-STING以影响免疫检查点抑制

Kang Liu1,2, Lidija A Wilhelms Garan1,3, Fang-Tsyr Lin1,2

  • 1Section of Hematology/Oncology, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.

Communications biology
|November 5, 2025
PubMed
概括

接触突变p53覆盖了一个关键的细胞循环开关,导致DNA复制错误并增加癌细胞对特定抑制剂的脆弱性. 这种机制也增强了抗癌免疫反应.

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