儿科侵入性角膜炎的趋势:物种分布的转变和改善结果
Kubra Aykac1, Emine Gulfem Anac2, Bera Enes Seyrek3
1Department of Pediatric Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
儿童的侵袭性候群病在非白虫Candida物种的增加,Candida parapsilosis显示增加了对可纳的耐药性. 改进的管理导致死亡率下降,强调需要特定物种的治疗策略.
科学领域:
- 儿童传染病 儿童传染病
- 菌类学 菌类学是指菌类学.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 侵入性角膜炎是住院儿童患病和死亡的关键原因,特别是那些患有潜在疾病或长时间住院的儿童.
- 了解Candida物种的趋势及其抗真菌敏感性对于有效治疗至关重要.
研究的目的:
- 为了评估儿童病人的入侵性Candida感染的11年流行病学.
- 分析抗真菌敏感性模式和临床结果.
- 确定影响死亡率的因素.
主要方法:
- 从2013年到2024年,对患有培养确认的侵入性Candida感染的儿科患者进行了回顾性分析.
- 收集的数据包括物种识别,抗真菌敏感性测试和临床结果.
- 进行了统计分析,以评估趋势和结果.
主要成果:
- 确定了158个侵袭性候群病发作,Candida albicans最初是最常见的物种,其次是Candida parapsilosis.
- 在研究期间观察到,非白动物物种,特别是Candida parapsilosis的流行率增加.
- 在Candida parapsilosis中,表现出最高的可纳耐药性 (13.2%). 整体死亡率为35.4%,通过早期取出导管 (OR=8.44) 显著降低.
结论:
- 非白菌的Candida物种越来越普遍,而Candida albicans的发病率正在下降.
- 改善的患者管理可能有助于显著降低死亡率.
- 在Candida parapsilosis中,阿醇耐药性的增加强调了及时,特定于物种的治疗策略的必要性,并强调了早期设备移除的重要性.
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