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Updated: Jan 12, 2026

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淋巴结环境驱动FSP1在转移性黑色素瘤中的向性

Mario Palma1, Milena Chaufan1, Cort B Breuer2,3

  • 1Department of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Nature
|November 5, 2025
PubMed
概括

No abstract available in PubMed .

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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