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来自伊朗的Onopordum acanthium L. (Asteraceae) 的植物化学丰富性和生物活性潜力

Mina Pakdelmoradlou¹, Hafize Yuca², Elif Beyza Özer^1,3

¹Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum, Türkiye.

|November 5, 2025

概括

一种药用植物Onopordum acanthium含有具有抗氧化和抗糖尿病功能的化合物. 这项研究证实了其在治疗氧化应激和神经退行性疾病方面的潜力,具有显著的抗微生物活性.

科学领域:

植物化学和药物鉴定学
自然产品化学自然产品化学
药用植物研究药用植物研究

背景情况:

传统上,Onopordum acanthium L. (Asteraceae) 的医学用途是公认的.
需要对其植物化学特征和生物活动有全面的了解.
研究各种植物部位 (根,茎,叶,花,果) 对于确定生物活性化合物的最佳来源至关重要.

研究的目的:

对Onopordum acanthium L.的形态,植物化学和生物特性进行详细的调查.
分析各种植物提取物的化合物成分并评估各种植物提取物的抗氧化,抗糖尿病,抗胆酶,抗微生物和基因毒性活性.
识别具有显著治疗潜力的特定植物部位和提取物.

主要方法:

来自不同植物器官 (根,茎,叶,花,果实) 的甲醇和水性提取物的制备.
使用LC-MS/MS进行植物化学分析,用于化合物的识别和定量.
在体外测定抗氧化剂 (ABTS,DPPH),抗糖尿病 (α-葡萄糖酶,α-氨基酶),抗胆酶 (AChE,BuChE),抗微生物 (MIC) 和基因毒性 (Ames,Allium测试) 活动.

主要成果:

酸和酸被确定为主要的化合物,特别是在根和花中.
水果甲醇提取物呈现出高总,黄和素含量,以及显著的抗氧化活性.
花和水果提取物显示出显著的抗糖尿病和抗微生物活性,而茎和根提取物显示出抗胆酶的潜力. 基因毒性测试证实了生物安全性,除了少数例外.

结论:

奥诺波尔多姆 (Onopordum acanthium L.) 是多种多样的化合物的丰富来源,具有显著的抗氧化,抗糖尿病和抗胆酶特性.
特定的提取物,特别是来自水果和花朵的提取物,在控制氧化应激,糖尿病和神经退行性疾病方面显示出有前途的治疗潜力.
这项研究证实了O. acanthium的传统用途,并支持其进一步发展为天然治疗剂的来源.

关键词:

抗胆化酶是一种抗胆化酶.这是一种抗糖尿病药物.星座科 (Asteraceae) 是一个植物.这是LC-MS/MS.在Onoopordum的acanthium上使用.

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