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TRIM8相关的非编码RNA面板作为狼性炎活动生物标志物

Mostafa Abdelnasier Abd Elgawad¹, Howayda Abdelhamid El Shinnawy¹, Sanaa Eissa²

¹Internal Medicine and Nephrology Department, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, 11566, Egypt.

Journal of translational medicine

|November 5, 2025

概括

研究人员确定了TRIM8基因和相关的非编码RNAs作为狼性炎 (LN) 活动的潜在生物标志物. 这些分子对LN的非侵入性监测充满希望,有助于临床管理.

科学领域:

分子生物学分子生物学
免疫学免疫学免疫学
发现生物标志物的发现.

背景情况:

狼性炎 (LN) 是系统性红斑狼 (SLE) 的严重并发症.
准确的生物标志物来评估LN活动对于有效的患者管理至关重要.
目前用于LN活动的诊断方法可能是侵入性的.

研究的目的:

评估TRIM8基因及其相关的非编码RNA (lnc-SSBP2-1:1和hsa-miR-126-5p) 作为LN活动的潜在的非侵入性生物标志物.
研究这些分子标记物在LN中的诊断和预后价值.

主要方法:

生物信息学分析用于识别LN中的候选mRNA和非编码RNA (ncRNAs).
使用实时PCR量化TRIM8,lnc-SSBP2-1:1,hsa-miR-126-5p的表达水平.
分析了来自活跃LN,不活跃LN和健康对照患者的样本.

主要成果:

在活跃的LN患者中,TRIM8mRNA和lnc-SSBP2-1:1 lncRNA显著上调.
在活跃的LN患者中,hsa-miR-126-5p显著下调.
疾病活动得分 (SLEDAI-2K) 与这些标记物的表达水平相关.

结论:

与TRIM8相关的非编码RNA调节网络显示出作为LN活动生物标志物的潜力.
这些发现表明一种新的,非侵入性的方法来监测LN.
这项研究可能会改善狼性炎患者的临床管理策略.

关键词:

在 TRIM8 中,这是一个hsa-miR-126-5pp.在SSBP2-1:1:1 中.生物标志物生物标志物疾病活动疾病活动狼性炎是一种神经炎.非编码RNA网络的非编码RNA网络

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相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...