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膝关节关节镜检查后静脉血栓栓塞的危险因素:系统性审查和元分析
Wei Zheng1, Xing Jin1, Mingming Yao2
1Department of Anesthesiology, Affiliated Hospital of Beihua University, Jilin, Jilin, 132000, China.
Thrombosis journal
|November 5, 2025
概括
接受膝关节关节镜检查 (KA) 的患者面临静脉血栓塞栓症 (VTE) 的风险增加. 关键的危险因素包括30岁以上的年龄,25岁以上的BMI和D-二次体水平升高,为预防策略提供信息.
科学领域:
- 整形外科手术 整形外科手术
- 血管医学 血管医学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 膝关节缩术 (KA) 程序越来越多地与术后静脉血栓栓塞 (VTE) 相关.
- 在KA之后的VTE带来了严重的患者安全问题.
- 确定特定的风险因素对于制定有效的预防策略至关重要.
研究的目的:
- 系统地评估和综合与VTE相关的风险因素.
- 建立基于证据的临床预防措施的科学基础,防止VTE后KA.
- 为高风险患者提供支持针对性干预措施的数据.
主要方法:
- 在PubMed,Embase,Web of Science和Cochrane图书馆 (2019-2025) 的综合文献搜索.
- 包括英语观察研究的VTE风险因素后KA.
- 使用纽卡斯尔-太华尺度进行质量评估,并对几率比率 (OR) 和95%置信区间 (CI) 的元分析.
主要成果:
- 分析了11项具有中等到高方法质量的观察性研究,涉及875,099名患者.
- 已确定VTE后KA的重要危险因素:年龄>30岁 (OR=1.59),BMI>25 (OR=1.23),D-二次数>0.62 mg/L (OR=5.69).
- 对所有确定的风险因素的统计学意义得到证实 (P < 0.014).
结论:
- 30岁以上的年龄,25岁以上的BMI和0.62 mg/L以上的D-二次数水平被证实是KA后VTE的显著风险因素.
- 有限的证据表明,口服避孕药的使用也可能增加KA后的VTE风险.
- 这些发现强调了需要对KA患者进行风险分层和量身定制的预防.
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