血和视网膜血管在 fundus 的动脉动脉指数之间的相关性:一个横截面研究
Zhenyan Wu1, Yu Xin1, Xue Jiang1
1Cardiovascular Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
European journal of medical research
|November 5, 2025
概括
血的无原体指数 (AIP) 与视网膜碎片尺寸 (FD) 和血管密度 (VD) 有负相关. 这些相关性在65岁及以上的个体中更为显著,这表明血脂和视网膜微血管变化之间存在联系.
科学领域:
- 眼科医生 眼科 眼科
- 心血管医学 心血管医学
- 医疗成像医学成像
背景情况:
- 血的异原体指数 (AIP) 是一种与动脉样硬化相关的基于脂质的标志物.
- 底部摄影和深度学习为分析视网膜微血管提供了非侵入性的方法.
研究的目的:
- 调查视网膜血管特征与AIP之间的相关性.
- 探索葡萄糖/脂质代谢,动脉样硬化标志物和微血管硬化之间的关系.
主要方法:
- 分析了651名住院患者的队列,按AIP四分位数分组.
- 深度学习从 fundus 图像中量化了视网膜血管参数 (FD,VD,MBVD).
- 线性回归和子组分析评估了AIP和视网膜指标之间的相关性.
主要成果:
- 在AIP组之间观察到人口,临床和脂质资料的显著差异.
- 视网膜碎形维度 (FD) 和血管密度 (VD) 在AIP四分位数中显示出显著的差异.
- 经过对混因素进行调整后,FD和VD与AIP水平呈负相关性.
- 在65岁及以上的人群中,相关性更为明显.
结论:
- AIP水平与视网膜FD和VD显著负相关.
- 在老年人 (≥65岁) 中,AIP,FD和VD之间的相关性尤其显著.
- 这项研究强调了视网膜成像在评估系统代谢和心血管风险方面的潜力.
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