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在怀孕期间传播的简单疹病毒:对病例的系统审查
Bethany Harrison1, Emily Clarke1,2
1Axess Sexual Health, Liverpool University Hospitals NHS Foundation Trust, Royal Liverpool University Hospital, Liverpool, UK.
The journal of obstetrics and gynaecology research
|November 6, 2025
概括
在怀孕期间传播的简单疹病毒 (HSV) 很少见,但很严重. 早期诊断和阿西克洛维尔治疗显著提高了母亲的存活率,突出了增加临床怀疑的必要性.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 在怀孕期间传播的单纯疹病毒 (HSV) 感染具有显著的死亡和发病风险.
- 这种罕见的疾病缺乏全面的国家指导方针和可靠的临床决策数据.
研究的目的:
- 系统地审查在孕妇和产后患者中传播的HSV病例.
- 确定临床特征,诊断方法,以及阿西克洛维尔对孕产妇存活率的影响.
主要方法:
- 在MEDLINE,EMBASE和谷歌进行了全面的文献搜索.
- 包括的研究是英语病例报告,系列,试验或评论,重点是孕妇或产后患者,实验室证实传播HSV.
- 数据提取和偏差评估由两个评论员独立进行.
主要成果:
- 对114例病例 (1966-2024) 的分析显示,大多数病例发生在妊娠的第三季度,呈HSV-2阳性.
- 发烧,肝功能异常和神经精神疾病表现等非特异性症状是常见的.
- 服用阿西克洛维尔 (0.88) 的母亲的存活率明显高于没有 (0.42) 的母亲的存活率,死亡前诊断为89.5%.
结论:
- 非特异性的临床表现需要高的怀疑指数来诊断妊娠期间传播的HSV.
- 建议包括强制报告和将传播的HSV纳入败血症管理指南.
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