在食物过敏中使用新的生物标志物和诊断工具
Supinda Bunyavanich1, Mubeccel Akdis2, M Cecilia Berin3
1Division of Allergy/Immunology, Department of Pediatrics, Department of Genetics & Genomic Sciences, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Allergy
|November 6, 2025
概括
诊断食物过敏正在超越传统的口服食物挑战. 新的细胞和分子测试,由人工智能提供动力,承诺更准确的诊断和治疗的监测.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏 诊断 过敏 诊断
背景情况:
- 双盲安慰剂控制的口服食物挑战 (DBPCFC) 已经是诊断IgE介导食物过敏的标准50年.
- 目前的诊断方法依赖于皮肤测试和血清IgE,补充临床病史.
研究的目的:
- 探索新兴的食品过敏诊断生物标志物和技术.
- 评估新测试的潜力,以取代或增强口服食品的挑战.
主要方法:
- 对效应细胞测定 (基和巨细胞激活) 的最新进展的审查.
- 探索新的抗体检测,T细胞检测,转录组学和代谢组学.
- 在诊断中考虑机器学习和人工智能.
主要成果:
- 效应细胞激活试验显示出临床应用的前景.
- 多原子方法与人工智能相结合,可能会提供新的诊断能力.
结论:
- 新的诊断工具正在出现,可以减少对口服食品的依赖.
- 这些进展可能会使更准确的食物过敏诊断和免疫治疗结果的监测成为可能.
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