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德里蒂斯比率是否可以作为预测较高的国际正常化比率值的标记?

Osman Onur Kaplan¹, Mesut Engin¹, Seray Yazgan²

¹Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Training and Research Hospital, University of Health Sciences, Bursa, Türkiye.

Biomarkers in medicine

|November 6, 2025

概括

德瑞蒂斯比率是肝脏健康的指标,可以预测在服用华法林的患者中,国际正常化比率 (INR) 水平升高. 较高的比率表明INR增加的可能性更大,这对于监测抗凝剂治疗至关重要.

科学领域:

肝病学和临床生物化学
药理学和治疗学药理学和治疗学

背景情况:

华法林治疗需要对国际正常化比率 (INR) 进行仔细监测,以确保疗效和预防并发症.
德里蒂斯比率,计算为阿斯巴酸氨基转移酶 (AST) 与氨基转移酶 (ALT) 水平的比率,是肝损伤的标志物.
研究用于预测INR波动的新生物标志物可以改善患者管理.

研究的目的:

确定De Ritis比率在预测华法林治疗患者INR值升高的预后意义.
为了探索肝酶比率与抗凝血控制之间的关联.

主要方法:

在接受华法林治疗的357名患者中进行了一项回顾性研究.
根据患者的INR值,患者被分为三个组:<2,2-3.5和>3.5.5.
在INR组中进行了统计分析,以比较人口统计和实验室数据,包括De Ritis比率.

主要成果:

在INR组中观察到De Ritis比率的显著差异 (p < 0.001).
在INR值高于3.5的患者中,De Ritis比率的中位数明显高于INR值较低的患者.
淋巴细胞计数也显示了群体之间的显著差异.

结论:

在接受华法林治疗的患者中,高的De Ritis比率与高的INR值有显著的相关性.
德里蒂斯比率可以作为一个有用的预后指标来预测更高的INR水平,有助于华法林治疗的管理.

关键词:

退款利率比率是指退款利率的比率.沃尔法林的战争生物标志物生物标志物过量服用过量服用过量治疗范围范围的治疗范围.

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