降低风险的卵巢切除术后患者的更年期症状管理
Andrew M Kaunitz1, Chanda Reese, JoAnn V Pinkerton
1Department of Obstetrics and Gynecology, University of Florida College of Medicine-Jacksonville, Jacksonville, FL; and Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, VA.
提高对遗传性妇科癌症检测的认识和降低成本意味着更多具有基因突变的个体面临关于减少风险的双边卵管切除术 (BSO) 的决定. 这影响了高风险患者的预防护理策略.
科学领域:
- 妇科瘤学 妇科瘤学
- 癌症遗传学 癌症遗传学
- 预防医学 预防医学
背景情况:
- 近几十年来,人们对遗传性妇科癌症的认识越来越大.
- 降低与遗传检测和预防策略相关的成本.
- 患有基因突变的个体面临手术决定的患病率增加.
研究的目的:
- 在遗传性妇科癌症患者中探索降低风险的双边卵管切除术 (BSO) 的决策过程.
- 分析影响BSO选择的因素.
- 了解增加BSO率对患者管理的影响.
主要方法:
- 关于遗传性妇科癌症的当前文献的综述.
- 对基因测试普及趋势的分析.
- 对预防性手术患者决策框架的检查.
主要成果:
- 更高的基因测试率,对突变的识别.
- 更频繁地考虑降低风险的手术,如BSO.
- 在患者咨询和手术规划方面出现的新挑战.
结论:
- 遗传性妇科癌症管理的景观正在向积极的风险降低转变.
- 及时和易于获得的遗传咨询对于明智的BSO决策至关重要.
- 需要进一步的研究来优化BSO战略和长期成果.
更多相关视频
06:18An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
08:46Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
相关概念视频
Menopause
Disorders of the Female Reproductive System
Hormonal Control of the Ovarian Cycle
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Hormonal Regulation of the Menstrual Cycle
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
Oogenesis
Mitral Valve Prolapse III: Nursing Management
