评估基托-凝-丁生物聚合物的吸水和In Vitro降解特性,用于组织工程
Onkar Kadam1, Tahsin Bennur2, Atul Kulkarni1
1Symbiosis Centre for Nanoscience and Nanotechnology, Symbiosis International (Deemed University), Pune, Maharashtra, India.
Biotechnology and applied biochemistry
|November 6, 2025
概括
这项研究开发了用于组织工程的新胆 - 凝 - pectin支架. 这些天然生物聚合物支架表现出改善的吸水和结构性质,显示出细胞粘附和增殖的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 聚合物化学 聚合物化学
背景情况:
- 支架对于人体组织工程至关重要,需要生物相容性和细胞粘附性.
- 合成生物聚合物经常表现出疏水性,并可能引起炎症,限制了它们的使用.
- 自然生物聚合物提供了增强的生物相容性,细胞粘附性和降低免疫性.
研究的目的:
- 开发和描述用于组织工程应用的新型天然生物聚合物支架.
- 为了研究结合素,凝和pectin对脚手架性能的影响.
- 评估这些复合支架在细胞粘附和增殖方面的潜力.
主要方法:
- 基托,凝和点被混合在不同的比例,并与甲交叉连接.
- 脚手架是使用冷解周期和热空气烤箱干燥制造的.
- 描述包括X射线衍射,扫描电子显微镜和里埃变换红外光谱学.
- 评估了水的吸收和降解特性.
主要成果:
- 将凝和pectin添加到chitosan中显著改善了脚手架的吸水能力.
- 复合材料支架的部分结晶性比仅含素的对照组更高.
- 结构和功能性质适合于组织工程应用.
结论:
- 基托桑-凝-pectin复合体支架显示了组织工程有前途的特性.
- 这些天然生物聚合物支架比合成替代品具有优势.
- 需要进一步的研究来探索它们在再生医学中的全部潜力.
更多相关视频
12:22Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
Published on: October 26, 2016
12.4K
05:26Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Published on: April 13, 2022
3.9K
相关概念视频
Deleterious Substances in Aggregate
Deleterious substances in aggregates can be detrimental to the quality and durability of concrete. These substances include organic impurities like loam, which interfere with cement hydration and are usually present in the sand. These prevent a good bond between aggregate and cement paste. Organic impurities can be detected using the colorimetric test, where the darkness of a solution after agitation indicates the level of organic content.
Another type of impurity is clay and fine material that...
Another type of impurity is clay and fine material that...
Testing Water Quality
When the quality of water for concrete preparation is uncertain, its impact on the setting time of cement and compressive strength of mortar is assessed by comparison with de-ionized or distilled water benchmarks. American Society for Testing and Materials (ASTM) C1602 requires the setting times to be within 90 minutes of the control, British Standard (BS) 3146:1980 allows a 30-minute variance in the initial setting, while British Standards European Norm (BS EN) 1008 specifies initial setting...
Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
Waterproofing and Anti-Bacterial Admixtures in Concrete
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...
Drying Shrinkage
When hardened concrete is exposed to air with a relative humidity of less than 100 percent, it begins to lose the free water within its capillaries. As this water evaporates, the water initially adsorbed onto the calcium silicate hydrates migrates towards these now empty spaces and eventually evaporates as well. Over time, as more water leaves, the volume of the concrete decreases, a phenomenon known as drying shrinkage.
A portion of this drying shrinkage can be reversed; if the concrete is...
A portion of this drying shrinkage can be reversed; if the concrete is...
