对甲基硫酸盐的阳性补丁试验反应:流行率,相关性和临床影响
Gabriele Casciola1, Luca Stingeni1, Leonardo Bianchi1
1Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Contact dermatitis
|November 6, 2025
概括
对甲硫酸盐 (SMB) 的接触过敏正在增加. 这项研究发现SMB补丁检测结果呈阳性的流行率很高,但这些反应在临床上并不重要,这表明SMB防腐剂通常是安全的.
科学领域:
- 皮肤病学 皮肤病学
- 过敏学 过敏学
- 接触性皮肤炎是什么
背景情况:
- 甲基硫酸盐 (SMB) 是各种产品中常见的防腐剂,包括局部配方,注射药物和食品.
- 对SMB接触过敏的病例越来越多,这凸显了需要了解阳性贴片试验反应和全身暴露影响的临床相关性.
研究的目的:
- 确定对甲基硫酸盐 (SMB) 的积极补丁试验反应的流行率和临床相关性.
- 评估含有SMB的局部麻醉溶液的安全性和耐受性,在SMB贴片试验阳性患者中.
主要方法:
- 从2024年1月到2025年4月,对550名患者进行了回顾性分析,用意大利基线系列测试,包括SMB,从2024年1月到2025年4月.
- 用SMB进行皮内测试和使用含有SMB的局部麻醉溶液进行挑战测试,这些测试对具有阳性贴片测试的患者进行.
主要成果:
- 在550名患者中,有16名 (2.9%) 患者对SMB的贴片测试反应呈阳性;然而,这些被认为不具有临床意义.
- 积极的中小企业补丁测试和MOAHLFA指数之间没有发现显著的关联,除了与年龄>40的关联.
- 所有16名阳性SMB贴片测试的患者都耐受了皮内SMB测试和局部麻醉的挑战,没有不良反应.
结论:
- 观察到对甲基硫酸盐 (SMB) 的积极补丁测试反应的高患病率,但这些反应缺乏临床相关性.
- 对SMB的阳性贴片测试似乎不违背含有SMB的局部麻醉剂的使用,表明耐受性良好.
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