分支链氨基酸对认知功能的有效性:系统性审查
Haya Majid1, Sajad Ul Islam2, Sunil Kohli2
1Department of Translational and Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, 110062, India.
Nutritional neuroscience
|November 6, 2025
概括
分链氨基酸 (BCAA) 可能会影响认知健康,但研究是混合的. 这次审查发现,一些研究表明有所改善,而另一些研究显示没有影响,强调需要更多的研究.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 生物化学 生物化学
背景情况:
- 分支链氨基酸 (BCAA),包括氨酸,异氨酸和氨酸,是必需的营养素.
- 新出现的证据表明,BCAA在调节认知健康方面可能发挥作用.
- 本系统性审查调查了BCAA对认知功能的影响的当前科学理解.
研究的目的:
- 系统地审查和综合关于BCAA补充对认知功能的影响的发现.
- 评估现有研究的证据质量.
- 识别知识上的差距,并建议未来的研究方向.
主要方法:
- 遵守PRISMA系统审查指南.
- 在2024年4月之前对电子数据库进行全面的文献搜索.
- 包括管理BCAA和评估人类参与者的认知功能的研究.
- 使用已建立的工具进行偏差风险评估 (科克兰偏差风险,纽卡斯尔-太华规模).
主要成果:
- 涉及353名参与者的8项研究符合纳入标准.
- 六项研究被评为高质量,两项研究被评为中质量.
- 五项研究报告没有显著的认知变化,而三项研究表明BCAA管理后有所改善.
结论:
- 补充BCAA对认知健康的影响不一致,似乎取决于剂量和持续时间等因素.
- 一些研究表明潜在的益处,而另一些研究显示没有重大影响,需要进一步调查.
- 更大的,设计精良的临床试验对于澄清BCAA与认知功能之间的关系以及开发有效的治疗策略至关重要.
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