关于LGR5的知识基础和研究领域:一本图书识别分析
Rong Ding1, Zemin Tang1, Rong Xu1
1Department of Pathology, Changde Hospital, Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City), Changde, Hunan, China.
Frontiers in research metrics and analytics
|November 6, 2025
概括
富含白的重复含有G蛋白结合受体5 (LGR5) 研究正在迅速发展,新兴的重点是LGR5 (+) 干细胞,炎症和瘤微环境. 未来的癌症疗法可能会针对瘤微环境中的LGR5 (+) 干细胞.
科学领域:
- 在瘤学瘤学.
- 干细胞生物学 干细胞生物学
- 生物信息学是一种生物信息学.
背景情况:
- 氨酸丰富的重复含有G蛋白结合受体5 (LGR5) 是干细胞的关键标记物,并与癌症干细胞功能如自我更新,转移和化学抵抗有关.
- 由于其可塑性,LGR5 (+) 癌症干细胞具有潜在的治疗点,但目前的研究数据有限.
研究的目的:
- 进行LGR5研究的文献分析,以了解其现状和进化趋势.
- 确定LGR5研究的关键研究领域,有影响力的贡献者和未来方向.
主要方法:
- 从Web of Science核心集合 (1999-2023) 中对2,187个出版物的图书法分析.
- 利用CiteSpace,VOSviewer,R软件,以及一个用于数据分析和可视化的图书识别在线分析平台.
主要成果:
- 美国是LGR5研究中最具生产力的国家. 荷兰是该领域早期研究的先驱.
- 克利弗斯被认为是最有影响力的作家. 肠道干细胞是一个突出的研究主题.
- 最近的研究热点包括"LGR5 (+) 干细胞"",炎症"和"瘤微环境",表明未来的研究重点.
结论:
- 全球LGR5研究正在积极推进.
- 本文献计量研究提供了LGR5研究的视觉概述,突出了当前的趋势和未来的研究途径,特别是向瘤微环境中的LGR5 (+) 干细胞.
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