帕克斯洛维德对动物模型大鼠骨系统形态发生的作用 (形态学研究)
Ali Abdollahi1, Majid Morovati-Sharifabad1, Elham Salehi1
1Department of Basic Science, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran.
Medical journal of the Islamic Republic of Iran
|November 6, 2025
概括
帕克斯洛维德 (尼马特里尔维尔/里托纳维尔) 没有导致大鼠胎儿的骨异常,尽管对母体体重和胎儿生长有一些影响. 这表明胎儿损害的风险最小,支持Paxlovid.
科学领域:
- 发育毒理学 发展毒理学
- 药理学 药理学是指药理学的学科.
- 甲状腺学 甲状腺学
背景情况:
- 帕克斯洛维德 (Paxlovid) 是一种口服抗病毒药物,包括尼尔马特里尔维尔 (NMV) 和里托纳维尔,正在开发用于SARS-CoV-2治疗.
- 研究治疗旨在减少COVID-19患者的严重疾病,住院和死亡风险.
- 在胚胎胎发育研究中,遵循了国际协调理事会的指导方针.
研究的目的:
- 评估Paxlovid对大鼠胎儿骨形态发生的作用.
- 评估在怀孕期间与帕克斯洛维德 (Paxlovid) 药物使用相关的潜在原性风险.
主要方法:
- 怀孕的老鼠接受了不同剂量的Paxlovid,与对照组.
- 测量了胎儿生长参数 (体重,冠状长,腹周长).
- 骨异常使用阿利扎林红色S和阿尔西安蓝色双色染色进行评估;使用ANOVA和Tukey的HSD测试进行统计分析.
主要成果:
- 在接受帕克斯洛维德治疗的组中,母亲的体重增加减少了.
- 来自治疗组的胎儿在怀孕21日体重减轻,冠长度减小,腹部周长减小.
- 在所有治疗组中的任何胎儿中都没有检测到骨异常.
结论:
- 帕克斯洛维德的使用并没有在老鼠胚胎中诱导骨发育不良.
- 观察到对母体体重和胎儿生长参数的影响表明有发育影响,但并非有毒性.
- 这些发现支持Paxlovid在胎儿骨发育方面具有有利的安全性.
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