高蛋白肠道食对严重病患者骨肌肉质量变化的影响:一项随机对照试验
Mir Mohammad Miri1, Mehran Kouchek1, Sara Salarian1
1Department of Critical Care Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
与标准护理相比,机械通风ICU患者的高蛋白肠道营养显著减少肌肉损失,改善营养状况. 这种干预可以帮助预防重症患者的肌肉衰竭和软弱.
科学领域:
- 临界护理医学 临界护理医学
- 临床营养学 临床营养学
- 肌肉生理学 肌肉生理学
背景情况:
- 危急病患者经常经历肌肉衰竭和软弱.
- 建议增加蛋白质摄入量以减轻这些影响.
- 这项研究研究了机械通风ICU患者的高蛋白肠道营养.
研究的目的:
- 为了比较机械通风ICU患者的蛋白质输送和肌肉损失.
- 评估高蛋白肠道营养与标准护理对肌肉质量的影响.
- 评估对营养状况的影响,用平衡来衡量.
主要方法:
- 一个随机的,开放的,受控的试验,涉及100名机械呼吸成年ICU患者.
- 患者接受高蛋白 (1.5 g/kg/天) 或标准 (1.0 g/kg/天) 肠道营养.
- 通过超声波测量肌肉厚度;平衡评估营养支持的充分性.
主要成果:
- 高蛋白质组的肌肉损失明显减少 (平均差异为-0.06和-0.27,P<0.001).
- 在高蛋白群中,在第3天和第5天观察到较高的平衡值 (P < 0.001).
- 研究了100名患者 (每组50名).
结论:
- 高蛋白质的肠道营养可以减轻机械通风ICU患者的肌肉损失.
- 这种方法似乎可以改善重症患者的营养状况.
- 进一步的研究可能会证实高蛋白饮食在重症监护机构的好处.
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