相关实验视频

Updated: Jan 12, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

放射治疗对高风险前列腺癌患者的ceRNA网络的影响

Somayeh Sadani¹, Solmaz Khalighfard², Sahar Naderinasab³

¹Ischemic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

|November 6, 2025

概括

放射治疗 (RT) 影响前列腺癌 (PCa) 基因表达网络. 在RT后,致癌性长非编码RNAs (lncRNAs),microRNAs (miRNAs) 和致癌基因在高风险PCa患者中显著下降,这表明ceRNA网络的监测潜力.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

放射治疗 (RT) 对于治疗前列腺癌 (PCa),减少复发和改善生存率至关重要.
确定RT反应的预测生物标志物是一个活跃的研究领域.
竞争的内源性RNA (ceRNA) 网络,包括长非编码RNA (lncRNA),microRNA (miRNA) 和信使RNA (mRNA),都与癌症进展有关.

研究的目的:

研究RT对高风险前列腺癌 (HrPCa) 中的ceRNA网络的影响.
为了确定监测HRPCa患者RT反应的潜在生物标志物.

主要方法:

利用基因表达综合 (GEO) 数据库进行差异基因表达分析.
使用TargetScan,miRanda和LncRNA2Target数据库来识别lncRNAs和miRNAs.
在RT前后对28名HRPCa患者和28名健康对照的全血样本进行实时PCR.

主要成果:

在HRPCa患者中鉴定了3,452个差异表达的基因.
选择了三个lncRNA,七个miRNA和九个mRNA作为候选生物标志物.
在RT后的HRPCa患者中观察到候选癌原性lncRNAs,miRNAs和癌基因的表达显著下降.

结论:

ceRNA网络分析显示,作为监测前列腺癌RT治疗反应的工具,它是有前途的.
需要进行更大的队列研究来验证这些发现及其临床实用性.

关键词:

生物标志物生物标志物 ceRNARNA是什么意思前列腺癌是前列腺癌.辐射疗法辐射疗法

更多相关视频

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

相关概念视频

Biological Effects of Radiation

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...