在镇静性胃肠内镜中增加了与晚期麻醉开始时间的普罗波福尔消费:从回归和机器学习模型的见解
Qiong Lan1, Zhuonan Sun1, Tian Wang1
1Department of Anesthesiology, Peking University Third Hospital, Beijing, China.
Frontiers in medicine
|November 6, 2025
概括
在胃肠道内镜检查期间,随着晚期麻醉开始时间的增加,propofol (麻醉剂) 的剂量会增加. 时间因素,比如白天的时间,对于优化普罗波的使用至关重要.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 时代药理学,研究时间如何影响药物反应,对propofol没有充分探索.
- 现有的普罗波福尔 (propofol) 管理模式缺乏时间变量集成.
- 时间变化在镇静过程中显著影响罗的使用.
研究的目的:
- 为了研究一天中的时间对在镇静性胃肠内镜期间的普罗波施用的影响.
- 为手动控制的普罗波福尔剂量开发具有时间变量的预测回归模型.
主要方法:
- 对接受镇静性肠道内镜检查的患者进行前性单中心队列研究.
- 根据麻醉开始时间 (8:00-10:00, 10:00-12:00, 13:00-15:00, 15:00-17:00) 将患者分为四组.
- 对外科手术期间特征,普罗波福尔剂量和与麻醉开始时间的相关性进行分析;开发线性回归模型.
主要成果:
- 分析了146例病例,显示了不同时间组的醇剂量 (诱导,维持,总量,每公斤/小时) 的显著差异.
- 在麻醉开始时间和所有普罗波福尔剂量参数之间观察到正相关性.
- 回归模型确定了麻醉开始时间,年龄,体重和持续时间,作为对普罗波福尔剂量的显著预测因素.
结论:
- 随着麻醉开始时间的延迟,propofol的剂量需求会增加.
- 在临床实践中,必须考虑时间因素来优化普罗波的使用.
- 需要进一步研究普罗波的时间药理学.
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