早期婴儿期评估骨健康的挑战:对现有技术的叙述性审查
Giorgia Pepe1, Letteria Anna Morabito1, Domenico Corica1
1Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Frontiers in endocrinology
|November 6, 2025
概括
由于缺乏指导方针,需要使用新的方法来评估婴儿的骨矿物质密度 (BMD). 射频超声波多谱仪 (REMS) 显示出对婴儿骨健康评估的前景.
科学领域:
- 儿科 儿科 儿科
- 放射学 放射学是一门学科.
- 生物物理学的生物物理.
背景情况:
- 缺乏确定的指导方针来诊断和管理婴儿的低骨矿物质密度 (BMD).
- 婴儿容易受到风险因素的影响,如母亲的维生素D缺乏,早产和低出生体重,因此需要对骨健康进行监测.
- 目前的骨质量评估方法 (生化标志物,DXA,QUS) 在新生儿和婴儿中存在局限性.
研究的目的:
- 突出需要新的方法来评估婴儿的骨健康.
- 引入射频声谱多谱测量 (REMS) 作为婴儿 BMD 评估的一个有前途的工具.
- 讨论REMS在敏感人群中大规模查策略的潜力.
主要方法:
- 对婴儿BMD的当前诊断工具的审查,包括生化标志物,DXA和QUS.
- 引入REMS技术,强调其无辐射性质,易用性,成本效益,灵敏性,特异性和可重复性.
- 讨论现有方法的局限性和REMS的优势.
主要成果:
- 雷姆斯被认为是查和监测新生儿和婴儿的BMD的潜在优越技术.
- 由于其安全性和性能特征,REMS比传统方法具有优势.
- 由于目前无法获得对儿科患者的验证的REMS参考切断值,存在很大的差距.
结论:
- 雷姆斯技术为评估婴儿骨矿物质密度提供了一个有前途的,无辐射的方法.
- 进一步的纵向研究对于建立REMS参考标准和为儿科骨健康开发诊断算法至关重要.
- 需要结合生化和仪器数据的综合方法,以有效诊断和管理婴儿低BMD.
相关概念视频
01:29Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
01:31Osteoclasts in Bone Remodeling
3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
01:40Bone Remodeling
40.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.2K