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肺癌中的瘤相关巨细胞:起源,功能异质性和治疗影响

Yeqing Tao¹, Jian Xiao², Yafang Li¹

¹Endoscopy Center, The First People's Hospital of Jiashan, Jiaxing, 314100, People's Republic of China.

Journal of inflammation research

|November 6, 2025

概括

肺癌中的瘤相关巨细胞 (TAM) 是多种多样的,有不同的亚型影响瘤生长,扩散和治疗耐药性. 针对这些巨细胞提供了新的治疗策略,以改善患者的治疗结果.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
细胞生物学细胞生物学

背景情况:

瘤相关巨细胞 (TAMs) 是肺癌瘤微环境 (TME) 中的关键免疫细胞.
TAMs包括异构的种群,包括单细胞衍生巨细胞 (MDMs) 和组织居民巨细胞 (TRMs),具有不同的作用.

研究的目的:

审查目前对TAM异质性在肺癌中的理解.
探索MDMs和TRMs在瘤进展,转移和治疗反应中的独特功能.
突出针对TAM的潜在治疗策略.

主要方法:

文献综述综合了最近关于TAMs在肺癌中的研究.
对MDM和TRM的时空异质性和功能作用的分析.
检查TAM对免疫抑制性TME,转移和治疗耐药性的贡献.

主要成果:

主要是MDMs驱动瘤生长和免疫抑制.
TRMs有助于组织平衡,但可以被重新编程以促进瘤.
两种MDM和TRM亚型都促进了免疫抑制的TME,帮助转移,并导致治疗耐药性.

结论:

了解TAM异质性对于开发向性肺癌疗法至关重要.
策略包括抑制TAM招募,重编程两极分化或阻止前瘤功能.
向TAM有望改善肺癌患者的治疗结果.

关键词:

免疫疗法免疫疗法巨细胞的两极分化治疗性抗药性是一种治疗性抗药性.瘤微环境是一个微环境.

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