葡萄糖和内皮生物标志物作为败血症的预后指标:系统性审查和元分析
Kamila R Daniyarova1, Zhanslu N Sarkulova1, Amin Tamadon2
1Department of Anesthesiology and Reanimatology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan.
MicrobiologyOpen
|November 6, 2025
概括
败血症生物标志物syndecan-1和endocan预测患者的死亡率. 在预测败血症死亡率的研究中,Endocan显示了更一致的结果.
科学领域:
- 生物医学研究的研究.
- 临床诊断 临床诊断 临床诊断
- 败血症的病理生理学
背景情况:
- 败血症引起的内皮功能障碍涉及葡萄糖的降解和内皮细胞的激活,导致器官衰竭和死亡率.
- 葡萄糖损害生物标志物显示出预后潜力,但它们的临床结果关联是可变的.
- 内皮细胞激活标志物也需要评估在败血症的预后效用.
研究的目的:
- 系统地评估与葡萄糖相关的生物标志物 (syndecan-1,海帕兰硫酸盐,氨酸) 和内皮激活标志物在败血症中的预后效用.
- 评估与死亡率,器官功能障碍和研究间异质性的关联.
- 为了确定可靠的生物标志物来预测败血症的结果.
主要方法:
- 包括4529名败血症患者在内的23项研究的系统审查和元分析,截至2025年5月.
- 两个独立的审查员对生物标志物度和临床结果 (死亡率,器官功能障碍,呼吸衰竭) 的数据提取.
- 使用纽卡斯尔-太华尺度 (NOS) 进行偏差风险评估.
主要成果:
- 增加的syndecan-1与增加的死亡率显著相关 (OR2.04),但显示出高异质性 (I2=84%).
- 增加的内分泌素还预测了死亡率,效果大小更强 (OR 5.06) 和异质性较低.
- 辛德肯-1与多个器官功能障碍综合征或呼吸衰竭没有显著的关联,具有很高的异质性.
结论:
- Syndecan-1和endocan是败血症患者死亡率的预后生物标志物.
- 与syndecan-1相比,Endocan显示出更大的研究间一致性和更强的死亡率相关性.
- 进一步的研究可能会澄清这些生物标志物在预测败血症中特定器官功能障碍中的作用.
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