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来自肠道微生物群的传染性致癌物:微生物从eubionts转变为pathobionts的机制

Yu-Chen Pai¹, Chung-Yen Huang², Li-Yu Lin¹

¹Graduate Institute of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan.

Journal of physiological investigation

|November 6, 2025

概括

肠道细菌失衡 (失生症) 与结肠癌有关. 主体上皮质压力推动了这种转变,影响了癌症的发展,并为精准医学提供了目标.

科学领域:

微生物学和瘤学
肠道微生物组研究研究
主体与微生物的相互作用

背景情况:

一个平衡的肠道微生物群 (eubiosis) 对于宿主健康至关重要.
微生物失衡 (不均衡),其特点是减少有益的微生物 (eubionts) 和增加机会性病原体 (pathobionts),与疾病有关,包括结肠炎相关的结肠直肠癌.
特定的细菌,如大肠杆菌,细菌易碎,和核菌具有致病因素,有助于结肠癌的发展.

研究的目的:

审查粘膜驱动器在塑造肠道微生物群中的作用.
检查皮内压力如何影响胆固醇和瘤原生菌群的发展.
要突出细菌从食人转变为促进癌症的病原生物的转变.

主要方法:

关于肠道微生物群组成和功能研究的文献综述.
对影响肠道环境的宿主上皮机制的分析.
检查细菌毒性因素及其致癌潜力.

主要成果:

主体上皮的功能,包括氧气调节,免疫反应和屏障完整性,显著塑造了肠道微生物群.
内皮质压力被确定为促进胆固醇和瘤原生微生物环境的关键因素.
细菌毒性因素 (例如,LPS,毒素) 通过诱导DNA损伤,增殖和炎症来促进瘤发生.

结论:

了解从eubiont转变为pathobiont的机制对于开发精准医学方法至关重要.
鉴定瘤发生过程中的关键宿主-微生物相互作用点,可以带来新的预防和治疗策略.
针对病原生物和调节宿主微生物动态为结直肠癌干预提供了潜在的潜力.

关键词:

屏障功能屏障功能刷边界边界刷边界边界大肠直肠癌的微生物组实验性的病原生物模型.肠道上皮细胞肠道上皮细胞侵袭性的病原生物.塑造微生物群的形成方式

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