在艾滋病毒感染者中,内化艾滋病毒污名和较低的艾滋病毒抗逆转录病毒疗法坚持之间的长度关联
Lydia N Drumright1, Joseph Ac Delaney1, Timothy Crawford2
1University of Washington, Seattle, United States.
Journal of acquired immune deficiency syndromes (1999)
|November 6, 2025
概括
内化艾滋病毒污名直接降低了抗逆转录病毒治疗的坚持. 了解这种联系对于开发改善艾滋病毒感染者的药物坚持和健康结果的干预措施至关重要.
科学领域:
- 公共卫生 公共卫生
- 临床医学 临床医学
- 心理学 心理学 心理学
背景情况:
- 内化艾滋病毒污名化 (IHS) 与较低的抗逆转录病毒疗法 (ART) 坚持和增加的艾滋病毒病毒,可能由抑郁症介导.
- 量化IHS对ART坚持的直接影响对于有针对性的干预措施至关重要.
研究的目的:
- 直接量化内部化艾滋病毒污名和ART坚持之间的关联.
- 为开发旨在改善艾滋病毒感染者的药物服药能力的干预措施提供信息.
主要方法:
- 利用来自艾滋病研究中心 (CFAR) 综合临床系统网络队列的纵向数据.
- 使用了具有非参数随机效应的通用线性潜伏和混合模型,将结果与GEE和MSM分析进行比较.
- 分析了患者报告的结果,包括IHS,ART坚持,抑郁和物质使用.
主要成果:
- 分析了13,119名艾滋病毒感染者 (PWH) 的队列,并进行了33,139次观察.
- 每一个IHS点的增加都与ART坚持率下降1.07%有关,即使在对人口和物质使用因素进行控制后也是如此.
- 当抑郁症得分被额外纳入模型时,这种关联减少到0.58%的减少.
结论:
- 内化艾滋病毒污名对ART坚持有直接的负面影响.
- 这种降低的附着性可以通过未抑制的病毒病症影响并发性健康状况.
- 对于有效的干预策略,进一步研究将IHS和ART坚持联系在一起的机制至关重要.
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