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In Vitro Synthesis of Modified mRNA for Induction of Protein Expression in Human Cells
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利用被破坏的DNA调节mRNA翻译以控制和顺序蛋白质表达

Jihun Choi1, Tae Ung Jeong1, Francis Cabanting1

  • 1Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.

Angewandte Chemie (International ed. in English)
|November 6, 2025
PubMed
概括

研究人员使用"受损"的DNA来控制信使RNA (mRNA) 的翻译速度. 这种方法可以通过调节蛋白质表达时间和速率而实现更安全,个性化的mRNA疗法,而不会产生有毒副产品.

关键词:
基础切除修复的基础切除修复修复DNA的修复DNA的修复调节的mRNA翻译 调节的mRNA翻译顺序表达式是指一个顺序表达式.在mRNA疗法中使用的mRNA疗法

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