唐氏综合征成人T细胞对SARS-CoV-2疫苗接种的反应 - 一项前性队列研究
Lobke C M Hensen1,2, Bianca M M Streng1, Femke van Wijk2
1Department of Paediatric Infectious Diseases and Immunology, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.
Human vaccines & immunotherapeutics
|November 6, 2025
概括
患有唐氏综合征 (DS) 的成年人在初始COVID-19疫苗接种后显示出可比的T细胞反应. 然而,与健康对照人群不同的是,DS个体的T细胞数量增强剂反应在DS个体下降.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 遗传学 是一个遗传学.
背景情况:
- 唐氏综合征 (DS) 与免疫功能障碍有关,增加了COVID-19的风险.
- 之前的研究表明,在DS的成年人中,在初级SARS-CoV-2疫苗接种后,抗体水平较低.
- 在DS中接种COVID-19疫苗后的细胞免疫力仍未得到充分研究.
研究的目的:
- 为了研究唐氏综合征的成年人T细胞对SARS-CoV-2疫苗接种的反应.
- 为了比较DS和健康对照 (HC) 的成年人之间的疫苗诱导的T细胞免疫力.
主要方法:
- 流细胞计分析了SARS-CoV-2特异性T细胞后尖峰重刺激.
- 使用IFNγ释放试验 (IGRA) 测量了干扰素玛 (IFNγ) 产量.
- 这项研究包括在初级疫苗和强剂疫苗接种后患有DS和HC (18-64岁) 的成年人.
主要成果:
- 患有DS的成年人表现出原始CD4+和CD8+T细胞的缺陷.
- 在DS和HC之间,在初级疫苗接种后,SARS-CoV-2特异性T细胞或IFNγ生产没有显著差异.
- 补充疫苗接种增加了HC的T细胞数量,但不是DS;IFNγ释放是可比的后补充.
结论:
- 功能性T细胞反应 (IFNγ产生) 在患有DS的成年人接受SARS-CoV-2初级疫苗接种和强剂疫苗接种后是可比的.
- 在DS中,mRNA增强疫苗接种后,T细胞反应的程度 (特定T细胞的百分比) 可能会降低.
- 由于在DS中观察到的抗体和T细胞异常,对T细胞-B细胞相互作用的进一步研究是有必要的.
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